Transcriptomopathies of pre- and post-symptomatic frontotemporal dementia-like mice with TDP-43 depletion in forebrain neurons

Transcriptomopathies of pre- and post-symptomatic frontotemporal dementia-like mice with TDP-43 depletion in forebrain neurons

Abstract TAR DNA-binding protein (TDP-43) is a ubiquitously expressed nuclear protein, which participates in a number of cellular processes and has been identified as the major pathological factor in amyotrophic lateral sclerosis (ALS) and frontotemporal lobar degeneration (FTLD). Here we constructe...

Full description

Bibliographic Details
Main Authors: Lien-Szu Wu, Wei-Cheng Cheng, Chia-Ying Chen, Ming-Che Wu, Yi-Chi Wang, Yu-Hsiang Tseng, Trees-Juen Chuang, C.-K. James Shen
Format: Article
Language:English
Published: BMC 2019-03-01
Series:Acta Neuropathologica Communications
Subjects:
Circular RNAs/ frontotemporal lobar degeneration/ loss-of-function/ Mis-processing/TDP-43
Online Access:http://link.springer.com/article/10.1186/s40478-019-0674-x

Internet

http://link.springer.com/article/10.1186/s40478-019-0674-x

Similar Items