Transcriptomopathies of pre- and post-symptomatic frontotemporal dementia-like mice with TDP-43 depletion in forebrain neurons

Transcriptomopathies of pre- and post-symptomatic frontotemporal dementia-like mice with TDP-43 depletion in forebrain neurons

Abstract TAR DNA-binding protein (TDP-43) is a ubiquitously expressed nuclear protein, which participates in a number of cellular processes and has been identified as the major pathological factor in amyotrophic lateral sclerosis (ALS) and frontotemporal lobar degeneration (FTLD). Here we constructe...

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Bibliographic Details
Main Authors: Lien-Szu Wu, Wei-Cheng Cheng, Chia-Ying Chen, Ming-Che Wu, Yi-Chi Wang, Yu-Hsiang Tseng, Trees-Juen Chuang, C.-K. James Shen
Format: Article
Language:English
Published: BMC 2019-03-01
Series:Acta Neuropathologica Communications
Subjects:
Circular RNAs/ frontotemporal lobar degeneration/ loss-of-function/ Mis-processing/TDP-43
Online Access:http://link.springer.com/article/10.1186/s40478-019-0674-x

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