Structure of the human heparan sulfate polymerase complex EXT1-EXT2

Structure of the human heparan sulfate polymerase complex EXT1-EXT2

Heparan sulfates are long and complex polysaccharides that mediate a large number of biological processes at the cell surface. Here, the authors provide structural and functional insights into the human EXT1-EXT2 complex that carries out the polymerization of heparan sulfate chains.

Bibliographic Details
Main Authors: Francisco Leisico, Juneina Omeiri, Christine Le Narvor, Joël Beaudouin, Michael Hons, Daphna Fenel, Guy Schoehn, Yohann Couté, David Bonnaffé, Rabia Sadir, Hugues Lortat-Jacob, Rebekka Wild
Format: Article
Language:English
Published: Nature Portfolio 2022-11-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-022-34882-6

Internet

https://doi.org/10.1038/s41467-022-34882-6

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