SIX2 Regulates Human β Cell Differentiation from Stem Cells and Functional Maturation In Vitro

SIX2 Regulates Human β Cell Differentiation from Stem Cells and Functional Maturation In Vitro

Summary: Generation of insulin-secreting β cells in vitro is a promising approach for diabetes cell therapy. Human embryonic stem cells (hESCs) and human induced pluripotent stem cells (hiPSCs) are differentiated to β cells (SC-β cells) and mature to undergo glucose-stimulated insulin secretion, but...

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Bibliographic Details
Main Authors: Leonardo Velazco-Cruz, Madeleine M. Goedegebuure, Kristina G. Maxwell, Punn Augsornworawat, Nathaniel J. Hogrebe, Jeffrey R. Millman
Format: Article
Language:English
Published: Elsevier 2020-05-01
Series:Cell Reports
Subjects:
diabetes
SIX2
islets
beta cells
stem cells
differentiation
Online Access:http://www.sciencedirect.com/science/article/pii/S2211124720306409

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http://www.sciencedirect.com/science/article/pii/S2211124720306409

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