Force-FAK signaling coupling at individual focal adhesions coordinates mechanosensing and microtissue repair

Force-FAK signaling coupling at individual focal adhesions coordinates mechanosensing and microtissue repair

How adhesive forces are transduced and integrated into biochemical signals at focal adhesions (FAs) is poorly understood. Here authors show that force- FAK signaling coupling coordinates cell migration and tissue-scale forces to promote microtissue repair.

Bibliographic Details
Main Authors: Dennis W. Zhou, Marc A. Fernández-Yagüe, Elijah N. Holland, Andrés F. García, Nicolas S. Castro, Eric B. O’Neill, Jeroen Eyckmans, Christopher S. Chen, Jianping Fu, David D. Schlaepfer, Andrés J. García
Format: Article
Language:English
Published: Nature Portfolio 2021-04-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-021-22602-5

Internet

https://doi.org/10.1038/s41467-021-22602-5

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