Force-FAK signaling coupling at individual focal adhesions coordinates mechanosensing and microtissue repair
How adhesive forces are transduced and integrated into biochemical signals at focal adhesions (FAs) is poorly understood. Here authors show that force- FAK signaling coupling coordinates cell migration and tissue-scale forces to promote microtissue repair.
| Main Authors: | , , , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Nature Portfolio
2021-04-01
|
| Series: | Nature Communications |
| Online Access: | https://doi.org/10.1038/s41467-021-22602-5 |
| _version_ | 1818425660228501504 |
|---|---|
| author | Dennis W. Zhou Marc A. Fernández-Yagüe Elijah N. Holland Andrés F. García Nicolas S. Castro Eric B. O’Neill Jeroen Eyckmans Christopher S. Chen Jianping Fu David D. Schlaepfer Andrés J. García |
| author_facet | Dennis W. Zhou Marc A. Fernández-Yagüe Elijah N. Holland Andrés F. García Nicolas S. Castro Eric B. O’Neill Jeroen Eyckmans Christopher S. Chen Jianping Fu David D. Schlaepfer Andrés J. García |
| author_sort | Dennis W. Zhou |
| collection | DOAJ |
| description | How adhesive forces are transduced and integrated into biochemical signals at focal adhesions (FAs) is poorly understood. Here authors show that force- FAK signaling coupling coordinates cell migration and tissue-scale forces to promote microtissue repair. |
| first_indexed | 2024-12-14T14:17:28Z |
| format | Article |
| id | doaj.art-7a26e4779fb9430c9f01584639edaf32 |
| institution | Directory Open Access Journal |
| issn | 2041-1723 |
| language | English |
| last_indexed | 2024-12-14T14:17:28Z |
| publishDate | 2021-04-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Nature Communications |
| spelling | doaj.art-7a26e4779fb9430c9f01584639edaf322022-12-21T22:58:10ZengNature PortfolioNature Communications2041-17232021-04-0112111310.1038/s41467-021-22602-5Force-FAK signaling coupling at individual focal adhesions coordinates mechanosensing and microtissue repairDennis W. Zhou0Marc A. Fernández-Yagüe1Elijah N. Holland2Andrés F. García3Nicolas S. Castro4Eric B. O’Neill5Jeroen Eyckmans6Christopher S. Chen7Jianping Fu8David D. Schlaepfer9Andrés J. García10Coulter Department of Biomedical Engineering, Georgia Institute of TechnologyPetit Institute for Bioengineering and Bioscience, Georgia Institute of TechnologyPetit Institute for Bioengineering and Bioscience, Georgia Institute of TechnologyWoodruff School of Mechanical Engineering, Georgia Institute of TechnologyCoulter Department of Biomedical Engineering, Georgia Institute of TechnologyPetit Institute for Bioengineering and Bioscience, Georgia Institute of TechnologyDepartment of Biomedical Engineering, Boston UniversityDepartment of Biomedical Engineering, Boston UniversityDepartment of Mechanical Engineering, Department of Biomedical Engineering, Department of Cell and Developmental Biology, University of MichiganMoores Cancer Center, Department of Obstetrics, Gynecology, and Reproductive Sciences, University of California, San DiegoPetit Institute for Bioengineering and Bioscience, Georgia Institute of TechnologyHow adhesive forces are transduced and integrated into biochemical signals at focal adhesions (FAs) is poorly understood. Here authors show that force- FAK signaling coupling coordinates cell migration and tissue-scale forces to promote microtissue repair.https://doi.org/10.1038/s41467-021-22602-5 |
| spellingShingle | Dennis W. Zhou Marc A. Fernández-Yagüe Elijah N. Holland Andrés F. García Nicolas S. Castro Eric B. O’Neill Jeroen Eyckmans Christopher S. Chen Jianping Fu David D. Schlaepfer Andrés J. García Force-FAK signaling coupling at individual focal adhesions coordinates mechanosensing and microtissue repair Nature Communications |
| title | Force-FAK signaling coupling at individual focal adhesions coordinates mechanosensing and microtissue repair |
| title_full | Force-FAK signaling coupling at individual focal adhesions coordinates mechanosensing and microtissue repair |
| title_fullStr | Force-FAK signaling coupling at individual focal adhesions coordinates mechanosensing and microtissue repair |
| title_full_unstemmed | Force-FAK signaling coupling at individual focal adhesions coordinates mechanosensing and microtissue repair |
| title_short | Force-FAK signaling coupling at individual focal adhesions coordinates mechanosensing and microtissue repair |
| title_sort | force fak signaling coupling at individual focal adhesions coordinates mechanosensing and microtissue repair |
| url | https://doi.org/10.1038/s41467-021-22602-5 |
| work_keys_str_mv | AT denniswzhou forcefaksignalingcouplingatindividualfocaladhesionscoordinatesmechanosensingandmicrotissuerepair AT marcafernandezyague forcefaksignalingcouplingatindividualfocaladhesionscoordinatesmechanosensingandmicrotissuerepair AT elijahnholland forcefaksignalingcouplingatindividualfocaladhesionscoordinatesmechanosensingandmicrotissuerepair AT andresfgarcia forcefaksignalingcouplingatindividualfocaladhesionscoordinatesmechanosensingandmicrotissuerepair AT nicolasscastro forcefaksignalingcouplingatindividualfocaladhesionscoordinatesmechanosensingandmicrotissuerepair AT ericboneill forcefaksignalingcouplingatindividualfocaladhesionscoordinatesmechanosensingandmicrotissuerepair AT jeroeneyckmans forcefaksignalingcouplingatindividualfocaladhesionscoordinatesmechanosensingandmicrotissuerepair AT christopherschen forcefaksignalingcouplingatindividualfocaladhesionscoordinatesmechanosensingandmicrotissuerepair AT jianpingfu forcefaksignalingcouplingatindividualfocaladhesionscoordinatesmechanosensingandmicrotissuerepair AT daviddschlaepfer forcefaksignalingcouplingatindividualfocaladhesionscoordinatesmechanosensingandmicrotissuerepair AT andresjgarcia forcefaksignalingcouplingatindividualfocaladhesionscoordinatesmechanosensingandmicrotissuerepair |