Screening of the Pathogen Box for inhibitors with dual efficacy against Giardia lamblia and Cryptosporidium parvum.

Screening of the Pathogen Box for inhibitors with dual efficacy against Giardia lamblia and Cryptosporidium parvum.

There is need for a more efficient cell-based assay amenable to high-throughput drug screening against Giardia lamblia. Here, we report the development of a screening method utilizing G. lamblia engineered to express red-shifted firefly luciferase. Parasite growth and replication were quantified usi...

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Bibliographic Details
Main Authors: Kelly M Hennessey, Ilse C Rogiers, Han-Wei Shih, Matthew A Hulverson, Ryan Choi, Molly C McCloskey, Grant R Whitman, Lynn K Barrett, Ethan A Merritt, Alexander R Paredez, Kayode K Ojo
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2018-08-01
Series:PLoS Neglected Tropical Diseases
Online Access:http://europepmc.org/articles/PMC6095626?pdf=render

Internet

http://europepmc.org/articles/PMC6095626?pdf=render

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