Human Hyaluronidase PH20 Potentiates the Antitumor Activities of Mesothelin-Specific CAR-T Cells Against Gastric Cancer

Human Hyaluronidase PH20 Potentiates the Antitumor Activities of Mesothelin-Specific CAR-T Cells Against Gastric Cancer

T cell infiltration into tumors is essential for successful immunotherapy against solid tumors. Herein, we found that the expression of hyaluronic acid synthases (HAS) was negatively correlated with patient survival in multiple types of solid tumors including gastric cancer. HA impeded in vitro anti...

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Bibliographic Details
Main Authors: Ruocong Zhao, Yuanbin Cui, Yongfang Zheng, Shanglin Li, Jiang Lv, Qiting Wu, Youguo Long, Suna Wang, Yao Yao, Wei Wei, Jie Yang, Bin-Chao Wang, Zhenfeng Zhang, Hui Zeng, Yangqiu Li, Peng Li
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-07-01
Series:Frontiers in Immunology
Subjects:
CAR-T cells
immunotherapy
hyaluronic acid
gastric cancer
tumor extracellular matrix
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2021.660488/full

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https://www.frontiersin.org/articles/10.3389/fimmu.2021.660488/full

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