An Imidazoline 2 Receptor Ligand Relaxes Mouse Aorta via Off-Target Mechanisms Resistant to Aging

An Imidazoline 2 Receptor Ligand Relaxes Mouse Aorta via Off-Target Mechanisms Resistant to Aging

Imidazoline receptors (IR) are classified into three receptor subtypes (I1R, I2R, and I3R) and previous studies showed that regulation of I2R signaling has neuroprotective potential. In order to know if I2R has a role in modulating vascular tone in health and disease, we evaluated the putative vasoa...

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Bibliographic Details
Main Authors: Francesc Jiménez-Altayó, Anna Cabrera, Andrea Bagán, Lydia Giménez-Llort, Pilar D’Ocon, Belén Pérez, Mercè Pallàs, Carmen Escolano
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-05-01
Series:Frontiers in Pharmacology
Subjects:
imidazoline receptor 2 ligands
mouse aorta
endothelium-independent vasodilatation
vascular aging
endothelial dysfunction
potassium and calcium ion channels
Online Access:https://www.frontiersin.org/articles/10.3389/fphar.2022.826837/full

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https://www.frontiersin.org/articles/10.3389/fphar.2022.826837/full

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