Inhibition of the HV1 voltage-gated proton channel compromises the viability of human polarized macrophages in a polarization- and ceramide-dependent manner

Inhibition of the HV1 voltage-gated proton channel compromises the viability of human polarized macrophages in a polarization- and ceramide-dependent manner

The human voltage-gated proton channel (HV1) provides an efficient proton extrusion pathway from the cytoplasm contributing to the intracellular pH regulation and the oxidative burst. Although its pharmacological inhibition was previously shown to induce cell death in various cell types, no such eff...

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Bibliographic Details
Main Authors: Tamas Kovacs, Bence Cs. Szabo, Rosemary Chandrakanthi Kothalawala, Virag Szekelyhidi, Peter Nagy, Zoltan Varga, Gyorgy Panyi, Florina Zakany
Format: Article
Language:English
Published: Frontiers Media S.A. 2024-12-01
Series:Frontiers in Immunology
Subjects:
HV1
cell viability
M1 macrophages
M2 macrophages
polarization
ceramide
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2024.1487578/full

Internet

https://www.frontiersin.org/articles/10.3389/fimmu.2024.1487578/full

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