A network-based approach reveals long non-coding RNAs associated with disease activity in lupus nephritis: key pathways for flare and potential biomarkers to be used as liquid biopsies

A network-based approach reveals long non-coding RNAs associated with disease activity in lupus nephritis: key pathways for flare and potential biomarkers to be used as liquid biopsies

ObjectiveA blood-based biomarker is needed to assess lupus nephritis (LN) disease activity, minimizing the need for invasive kidney biopsies. Long non-coding RNAs (lncRNAs) are known to regulate gene expression, appear to be stable in human plasma, and can serve as non-invasive biomarkers.MethodsTra...

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Bibliographic Details
Main Authors: George Sentis, Catherine Loukogiannaki, Nikos Malissovas, Dionysis Nikolopoulos, Theodora Manolakou, Sofia Flouda, Maria Grigoriou, Aggelos Banos, Dimitrios T. Boumpas, Anastasia Filia
Format: Article
Language:English
Published: Frontiers Media S.A. 2023-07-01
Series:Frontiers in Immunology
Subjects:
lupus nephritis
long non-coding RNAs
WGCNA
disease activity
ceRNA
blood-based biomarker
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2023.1203848/full

Internet

https://www.frontiersin.org/articles/10.3389/fimmu.2023.1203848/full

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