EX-527 Prevents the Progression of High-Fat Diet-Induced Hepatic Steatosis and Fibrosis by Upregulating SIRT4 in Zucker Rats

EX-527 Prevents the Progression of High-Fat Diet-Induced Hepatic Steatosis and Fibrosis by Upregulating SIRT4 in Zucker Rats

Sirtuin (SIRT) is known to prevent nonalcoholic fatty liver disease (NAFLD); however, the role of SIRT4 in the progression of hepatic fibrosis remains unknown. We hypothesize that EX-527, a selective SIRT1 inhibitor, can inhibit the progression of high-fat diet (HFD)-induced hepatic fibrosis. We fou...

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Bibliographic Details
Main Authors: Amit Kundu, Prasanta Dey, Jae Hyeon Park, In Su Kim, Seung Jun Kwack, Hyung Sik Kim
Format: Article
Language:English
Published: MDPI AG 2020-04-01
Series:Cells
Subjects:
EX-527
fatty liver
liver fibrosis
inflammation
SIRT4
Online Access:https://www.mdpi.com/2073-4409/9/5/1101

Internet

https://www.mdpi.com/2073-4409/9/5/1101

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