A novel anti-CD22 scFv–apoptin fusion protein induces apoptosis in malignant B-cells

A novel anti-CD22 scFv–apoptin fusion protein induces apoptosis in malignant B-cells

Abstract CD22 marker is a highly internalizing antigen which is located on the surface of B-cells and is being used as a promising target for treatment of B cell malignancies. Monoclonal antibodies targeting CD22 have been introduced and some are currently under investigation in clinical trials. Bui...

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Bibliographic Details
Main Authors: Solmaz Agha Amiri, Soraya Shahhosseini, Najmeh Zarei, Dorsa Khorasanizadeh, Elahe Aminollahi, Faegheh Rezaie, Mehryar Zargari, Mohammad Azizi, Vahid Khalaj
Format: Article
Language:English
Published: SpringerOpen 2017-06-01
Series:AMB Express
Subjects:
CD22
Single chain variable fragment
Apoptin
Fusion protein
Immunotherapy
Apoptosis
Online Access:http://link.springer.com/article/10.1186/s13568-017-0410-5

Internet

http://link.springer.com/article/10.1186/s13568-017-0410-5

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