Drug targeting Nsp1-ribosomal complex shows antiviral activity against SARS-CoV-2

Drug targeting Nsp1-ribosomal complex shows antiviral activity against SARS-CoV-2

The SARS-CoV-2 non-structural protein 1 (Nsp1) contains an N-terminal domain and C-terminal helices connected by a short linker region. The C-terminal helices of Nsp1 (Nsp1-C-ter) from SARS-CoV-2 bind in the mRNA entry channel of the 40S ribosomal subunit and blocks mRNA entry, thereby shutting down...

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Bibliographic Details
Main Authors: Mohammad Afsar, Rohan Narayan, Md Noor Akhtar, Deepakash Das, Huma Rahil, Santhosh Kambaiah Nagaraj, Sandeep M Eswarappa, Shashank Tripathi, Tanweer Hussain
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2022-03-01
Series:eLife
Subjects:
SARS-CoV-2
Nsp1
ribosome
translation
Online Access:https://elifesciences.org/articles/74877

Internet

https://elifesciences.org/articles/74877

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