Drug targeting Nsp1-ribosomal complex shows antiviral activity against SARS-CoV-2
The SARS-CoV-2 non-structural protein 1 (Nsp1) contains an N-terminal domain and C-terminal helices connected by a short linker region. The C-terminal helices of Nsp1 (Nsp1-C-ter) from SARS-CoV-2 bind in the mRNA entry channel of the 40S ribosomal subunit and blocks mRNA entry, thereby shutting down...
Main Authors: | , , , , , , , , |
---|---|
Format: | Article |
Language: | English |
Published: |
eLife Sciences Publications Ltd
2022-03-01
|
Series: | eLife |
Subjects: | |
Online Access: | https://elifesciences.org/articles/74877 |