Therapeutic effects of Pulsatilla koreana Nakai extract on ovalbumin-induced allergic rhinitis by inhibition of Th2 cell activation and differentiation via the IL-4/STAT6/GATA3 pathway

Therapeutic effects of Pulsatilla koreana Nakai extract on ovalbumin-induced allergic rhinitis by inhibition of Th2 cell activation and differentiation via the IL-4/STAT6/GATA3 pathway

Allergic rhinitis (AR), caused by immunoglobulin E (IgE)-mediated inflammation, generally occurs in the upper respiratory tract. T helper type 2 (Th2) cell-mediated cytokines, including interleukin (IL)-4, IL-5, and IL-13, are important factors in AR pathogenesis. Despite various treatment options,...

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Bibliographic Details
Main Authors: Dong Ho Jung, Ami Lee, Youn-Hwan Hwang, Myung-A. Jung, Bo-Jeong Pyun, Joo Young Lee, Taesoo Kim, Kwang Hoon Song, Kon-Young Ji
Format: Article
Language:English
Published: Elsevier 2023-06-01
Series:Biomedicine & Pharmacotherapy
Subjects:
Pulsatilla koreana Nakai
Allergic rhinitis
Th2 differentiation
Th2 activation
Th2 cytokine
IL-4/STAT6/GATA3 pathway
Online Access:http://www.sciencedirect.com/science/article/pii/S0753332223005188

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http://www.sciencedirect.com/science/article/pii/S0753332223005188

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