Allogeneic and xenogeneic lymphoid reconstitution in a RAG2−/−IL2RGy/− severe combined immunodeficient pig: A preclinical model for intrauterine hematopoietic transplantation

Allogeneic and xenogeneic lymphoid reconstitution in a RAG2−/−IL2RGy/− severe combined immunodeficient pig: A preclinical model for intrauterine hematopoietic transplantation

Mice with severe combined immunodeficiency are commonly used as hosts of human cells. Size, longevity, and physiology, however, limit the extent to which immunodeficient mice can model human systems. To address these limitations, we generated RAG2−/−IL2RGy/− immunodeficient pigs and demonstrate succ...

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Bibliographic Details
Main Authors: Renan B. Sper, Jessica Proctor, Odessa Lascina, Ling Guo, Kathryn Polkoff, Tobias Kaeser, Sean Simpson, Luke Borst, Katherine Gleason, Xia Zhang, Bruce Collins, Yanet Murphy, Jeffrey L. Platt, Jorge A. Piedrahita
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-10-01
Series:Frontiers in Veterinary Science
Subjects:
severe combined immunodeficiency
pig
xenotransplantation
allotransplantation
hematopoietic
RAG2
Online Access:https://www.frontiersin.org/articles/10.3389/fvets.2022.965316/full

Internet

https://www.frontiersin.org/articles/10.3389/fvets.2022.965316/full

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