Epididymis response partly compensates for spermatozoa oxidative defects in snGPx4 and GPx5 double mutant mice.

Epididymis response partly compensates for spermatozoa oxidative defects in snGPx4 and GPx5 double mutant mice.

We report here that spermatozoa of mice lacking both the sperm nucleus glutathione peroxidase 4 (snGPx4) and the epididymal glutathione peroxidase 5 (GPx5) activities display sperm nucleus structural abnormalities including delayed and defective nuclear compaction, nuclear instability and DNA damage...

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Bibliographic Details
Main Authors: Anaïs Noblanc, Manon Peltier, Christelle Damon-Soubeyrand, Nicolas Kerchkove, Eléonore Chabory, Patrick Vernet, Fabrice Saez, Rémi Cadet, Laurent Janny, Hanae Pons-Rejraji, Marcus Conrad, Joël R Drevet, Ayhan Kocer
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2012-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3375294?pdf=render

Internet

http://europepmc.org/articles/PMC3375294?pdf=render

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