Lignan-Rich Sesame (<i>Sesamum indicum</i> L.) Cultivar Exhibits In Vitro Anti-Cholinesterase Activity, Anti-Neurotoxicity in Amyloid-β Induced SH-SY5Y Cells, and Produces an In Vivo Nootropic Effect in Scopolamine-Induced Memory Impaired Mice

Lignan-Rich Sesame (<i>Sesamum indicum</i> L.) Cultivar Exhibits In Vitro Anti-Cholinesterase Activity, Anti-Neurotoxicity in Amyloid-β Induced SH-SY5Y Cells, and Produces an In Vivo Nootropic Effect in Scopolamine-Induced Memory Impaired Mice

Alzheimer’s disease, a major cause of dementia, is characterized by impaired cholinergic function, increased oxidative stress, and amyloid cascade induction. Sesame lignans have attracted considerable attention owing to their beneficial effects on brain health. This study investigated the neuroprote...

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Bibliographic Details
Main Authors: Min-Young Kim, Sungup Kim, Jeongeun Lee, Jung-In Kim, Eunyoung Oh, Sang-Woo Kim, Eunsoo Lee, Kwang-Soo Cho, Choon-Song Kim, Myoung-Hee Lee
Format: Article
Language:English
Published: MDPI AG 2023-05-01
Series:Antioxidants
Subjects:
sesame
lignan
amyloid-β
neurotoxicity
neuronal regeneration
Online Access:https://www.mdpi.com/2076-3921/12/5/1110

Internet

https://www.mdpi.com/2076-3921/12/5/1110

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