Somatic Mutations of Hematopoietic Cells Are an Additional Mechanism of Body Aging, Conducive to Comorbidity and Increasing Chronification of Inflammation

It is known that the development of foci of chronic inflammation usually accompanies body aging. In these foci, senescent cells appear with a pro-inflammatory phenotype that helps maintain inflammation. Their removal with the help of senolytics significantly improves the general condition of the bod...

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Bibliographic Details
Main Authors: Yegor E. Yegorov, Anastasia V. Poznyak, Evgeny E. Bezsonov, Alexander D. Zhuravlev, Nikita G. Nikiforov, Khava S. Vishnyakova, Alexander N. Orekhov
Format: Article
Language:English
Published: MDPI AG 2022-03-01
Series:Biomedicines
Subjects:
Online Access:https://www.mdpi.com/2227-9059/10/4/782