Combined Protein- and Ligand-Observed NMR Workflow to Screen Fragment Cocktails against Multiple Proteins: A Case Study Using Bromodomains
As fragment-based drug discovery has become mainstream, there has been an increase in various screening methodologies. Protein-observed <sup>19</sup>F (PrOF) NMR and <sup>1</sup>H CPMG NMR are two fragment screening assays that have complementary advantages. Here, we sought t...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
MDPI AG
2020-08-01
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| Series: | Molecules |
| Subjects: | |
| Online Access: | https://www.mdpi.com/1420-3049/25/17/3949 |