Derivation and travelling wave analysis of phenotype-structured haptotaxis models of cancer invasion

We formulate haptotaxis models of cancer invasion wherein the infiltrating cancer cells can occupy a spectrum of states in phenotype space, ranging from ‘fully mesenchymal’ to ‘fully epithelial’. The more mesenchymal cells are those that display stronger haptotaxis responses and have greater capacit...

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Bibliographic Details
Main Authors: Tommaso Lorenzi, Fiona R. Macfarlane, Kevin J. Painter
Format: Article
Language:English
Published: Cambridge University Press 2025-04-01
Series:European Journal of Applied Mathematics
Subjects:
Online Access:https://www.cambridge.org/core/product/identifier/S0956792524000056/type/journal_article