Delineation of the distinct inflammatory signaling roles of TAK1 and JAK1/3 in the CIA model of rheumatoid arthritis

Delineation of the distinct inflammatory signaling roles of TAK1 and JAK1/3 in the CIA model of rheumatoid arthritis

Abstract Rheumatoid arthritis (RA) is a complex autoimmune disease characterized by hyperactive immune cells within the joints, which leads to inflammation, bone degeneration, and chronic pain. For several decades, frontline immunomodulators such as the anti‐tumor necrosis factor (TNF) biologics ada...

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Bibliographic Details
Main Authors: Robert Freeze, Kelly W. Yang, Timothy Haystead, Philip Hughes, Scott Scarneo
Format: Article
Language:English
Published: Wiley 2023-08-01
Series:Pharmacology Research & Perspectives
Subjects:
inflammation
rheumatoid arthritis
small molecule
TAK1
therapeutics
TNF
Online Access:https://doi.org/10.1002/prp2.1124

Internet

https://doi.org/10.1002/prp2.1124

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