Explaining the determinants of first phase HIV decay dynamics through the effects of stage-dependent drug action.

A recent investigation of the effect of different antiretroviral drug classes on first phase dynamics of HIV RNA plasma virus levels has indicated that drugs acting at stages closer to viral production, such as the integrase inhibitor raltegravir, can produce a steeper first phase decay slope that m...

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Bibliographic Details
Main Authors: James B Gilmore, Anthony D Kelleher, David A Cooper, John M Murray
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2013-01-01
Series:PLoS Computational Biology
Online Access:http://europepmc.org/articles/PMC3610612?pdf=render