Modulation of the NOTCH1 Pathway by LUNATIC FRINGE Is Dominant over That of MANIC or RADICAL FRINGE

Modulation of the NOTCH1 Pathway by LUNATIC FRINGE Is Dominant over That of MANIC or RADICAL FRINGE

Fringes are glycosyltransferases that transfer a GlcNAc to <i>O</i>-fucose residues on Epidermal Growth Factor-like (EGF) repeats. Three Fringes exist in mammals: LUNATIC FRINGE (LFNG), MANIC FRINGE (MFNG), and RADICAL FRINGE (RFNG). Fringe modification of <i>O</i>-fucose on...

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Bibliographic Details
Main Authors: Florian Pennarubia, Alison V. Nairn, Megumi Takeuchi, Kelley W. Moremen, Robert S. Haltiwanger
Format: Article
Language:English
Published: MDPI AG 2021-09-01
Series:Molecules
Subjects:
NOTCH1
Fringe
EGF-like domains
<i>O</i>-fucosylation
glycosylation
Online Access:https://www.mdpi.com/1420-3049/26/19/5942

Internet

https://www.mdpi.com/1420-3049/26/19/5942

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