Combined Inhibition of FOSL-1 and YAP Using siRNA-Lipoplexes Reduces the Growth of Pancreatic Tumor

Combined Inhibition of FOSL-1 and YAP Using siRNA-Lipoplexes Reduces the Growth of Pancreatic Tumor

Pancreatic cancer evades most of the current therapies and there is an urgent need for new treatments that could efficiently eliminate this aggressive tumor, such as the blocking of routes driving cell proliferation. In this work, we propose the use of small interfering RNA (siRNA) to inhibit the co...

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Bibliographic Details
Main Authors: Lara Diego-González, Andrea Fernández-Carrera, Ana Igea, Amparo Martínez-Pérez, M. Elisabete C. D. Real Oliveira, Andreia C. Gomes, Carmen Guerra, Mariano Barbacid, África González-Fernández, Rosana Simón-Vázquez
Format: Article
Language:English
Published: MDPI AG 2022-06-01
Series:Cancers
Subjects:
pancreatic ductal adenocarcinoma
nanomedicine
liposomes
gene silencing
KRAS
Hippo pathway
Online Access:https://www.mdpi.com/2072-6694/14/13/3102

Internet

https://www.mdpi.com/2072-6694/14/13/3102

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