Psoralen alleviates radiation-induced bone injury by rescuing skeletal stem cell stemness through AKT-mediated upregulation of GSK-3β and NRF2

Psoralen alleviates radiation-induced bone injury by rescuing skeletal stem cell stemness through AKT-mediated upregulation of GSK-3β and NRF2

Abstract Background Repairing radiation-induced bone injuries remains a significant challenge in the clinic, and few effective medicines are currently available. Psoralen is a principal bioactive component of Cullen corylifolium (L.) Medik and has been reported to have antitumor, anti-inflammatory,...

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Bibliographic Details
Main Authors: Bo-Feng Yin, Zhi-Ling Li, Zi-Qiao Yan, Zheng Guo, Jia-Wu Liang, Qian Wang, Zhi-Dong Zhao, Pei-Lin Li, Rui-Cong Hao, Meng-Yue Han, Xiao-Tong Li, Ning Mao, Li Ding, Da-Fu Chen, Yue Gao, Heng Zhu
Format: Article
Language:English
Published: BMC 2022-06-01
Series:Stem Cell Research & Therapy
Subjects:
Psoralen
Radiation-induced bone injuries
Skeletal stem cells
NRF2
Online Access:https://doi.org/10.1186/s13287-022-02911-2

Internet

https://doi.org/10.1186/s13287-022-02911-2

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