Artificial Intelligence/Machine Learning-Driven Small Molecule Repurposing via Off-Target Prediction and Transcriptomics

Artificial Intelligence/Machine Learning-Driven Small Molecule Repurposing via Off-Target Prediction and Transcriptomics

The process of discovering small molecule drugs involves screening numerous compounds and optimizing the most promising ones, both in vitro and in vivo. However, approximately 90% of these optimized candidates fail during trials due to unexpected toxicity or insufficient efficacy. Current concepts w...

Full description

Bibliographic Details
Main Authors: Mohan Rao, Eric McDuffie, Clifford Sachs
Format: Article
Language:English
Published: MDPI AG 2023-10-01
Series:Toxics
Subjects:
drug repurposing
off-target prediction
AI/ML
cheminformatics
transcriptomics
due diligence
Online Access:https://www.mdpi.com/2305-6304/11/10/875

Internet

https://www.mdpi.com/2305-6304/11/10/875

Similar Items