Interleukin-1 blockade with RPH-104 in patients with acute ST-elevation myocardial infarction: study design and rationale

Interleukin-1 blockade with RPH-104 in patients with acute ST-elevation myocardial infarction: study design and rationale

Abstract Background Myocardial injury of ST-segment elevation myocardial infarction (STEMI) initiates an intense inflammatory response that contributes to further damage and is a predictor of increased risk of death or heart failure (HF). Interleukin-1 (IL-1) is a key mediator of local and systemic...

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Bibliographic Details
Main Authors: M. Samsonov, V. Bogin, B. W. Van Tassell, A. Abbate
Format: Article
Language:English
Published: BMC 2021-04-01
Series:Journal of Translational Medicine
Subjects:
STEMI
Myocardial infarction
Cardiovascular diseases
Inflammation
RPH-104
Trial design
Online Access:https://doi.org/10.1186/s12967-021-02828-z

Internet

https://doi.org/10.1186/s12967-021-02828-z

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