A Combined In Vitro/In Silico Approach to Identifying Off-Target Receptor Toxicity

A Combined In Vitro/In Silico Approach to Identifying Off-Target Receptor Toxicity

Summary: Many xenobiotics can bind to off-target receptors and cause toxicity via the dysregulation of downstream transcription factors. Identification of subsequent off-target toxicity in these chemicals has often required extensive chemical testing in animal models. An alternative, integrated in v...

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Bibliographic Details
Main Authors: Joseph Leedale, Kieran J. Sharkey, Helen E. Colley, Áine M. Norton, David Peeney, Chantelle L. Mason, Jean G. Sathish, Craig Murdoch, Parveen Sharma, Steven D. Webb
Format: Article
Language:English
Published: Elsevier 2018-06-01
Series:iScience
Online Access:http://www.sciencedirect.com/science/article/pii/S2589004218300671

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http://www.sciencedirect.com/science/article/pii/S2589004218300671

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