Elevated hepatic DPP4 activity promotes insulin resistance and non-alcoholic fatty liver disease

Elevated hepatic DPP4 activity promotes insulin resistance and non-alcoholic fatty liver disease

Objective: Increased hepatic expression of dipeptidyl peptidase 4 (DPP4) is associated with non-alcoholic fatty liver disease (NAFLD). Whether this is causative for the development of NAFLD is not yet clarified. Here we investigate the effect of hepatic DPP4 overexpression on the development of live...

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Bibliographic Details
Main Authors: Christian Baumeier, Luisa Schlüter, Sophie Saussenthaler, Thomas Laeger, Maria Rödiger, Stella Amelie Alaze, Louise Fritsche, Hans-Ulrich Häring, Norbert Stefan, Andreas Fritsche, Robert Wolfgang Schwenk, Annette Schürmann
Format: Article
Language:English
Published: Elsevier 2017-10-01
Series:Molecular Metabolism
Subjects:
CD36
DPP4
GLP-1
Insulin resistance
NAFLD
PPARγ
Online Access:http://www.sciencedirect.com/science/article/pii/S2212877817305318

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http://www.sciencedirect.com/science/article/pii/S2212877817305318

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