Endothelium-dependent relaxation in response to poly-L-arginine in canine coronary arteries: implications about hyperpolarization as a mechanism of vasodilatation

Endothelium-dependent relaxation in response to poly-L-arginine in canine coronary arteries: implications about hyperpolarization as a mechanism of vasodilatation

OBJECTIVE: To study the mechanism by which poly-L-arginine mediates endothelium-dependent relaxation. METHODS: Vascular segments with and without endothelium were suspended in organ chambers filled with control solution maintained at 37ºC and bubbled with 95% O2 / 5% CO2. Used drugs: indomethacin, a...

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Bibliographic Details
Main Authors: Paulo R. B. Evora, Paul J. Pearson, Alfredo José Rodrigues, Fernanda Viaro, Hartzell V. Schaff
Format: Article
Language:English
Published: Sociedade Brasileira de Cardiologia (SBC) 2003-06-01
Series:Arquivos Brasileiros de Cardiologia
Subjects:
poly-L-arginine
polycations
nitric oxide
EDHF
endothelium
Online Access:http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0066-782X2003000600005

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http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0066-782X2003000600005

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