Tryptophan Catabolism and Response to Therapy in Locally Advanced Rectal Cancer (LARC) Patients

Tryptophan Catabolism and Response to Therapy in Locally Advanced Rectal Cancer (LARC) Patients

In locally advanced rectal cancer patients (LARC), preoperative chemoradiation improves local control and sphincter preservation. The response rate to treatment varies substantially between 20 and 30%, and it is an important prognostic factor. Indeed, nonresponsive patients are subjected to higher r...

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Bibliographic Details
Main Authors: Sara Crotti, Alessandra Fraccaro, Chiara Bedin, Antonella Bertazzo, Valerio Di Marco, Salvatore Pucciarelli, Marco Agostini
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-10-01
Series:Frontiers in Oncology
Subjects:
tryptophan
rectal cancer
IDO1
TDO2
TPH1
kynurenine pathway
Online Access:https://www.frontiersin.org/article/10.3389/fonc.2020.583228/full

Internet

https://www.frontiersin.org/article/10.3389/fonc.2020.583228/full

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