LAMC2 marks a tumor-initiating cell population with an aggressive signature in pancreatic cancer

LAMC2 marks a tumor-initiating cell population with an aggressive signature in pancreatic cancer

Abstract Background Tumor-initiating cells (TIC), also known as cancer stem cells, are considered a specific subpopulation of cells necessary for cancer initiation and metastasis; however, the mechanisms by which they acquire metastatic traits are not well understood. Methods LAMC2 transcriptional l...

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Bibliographic Details
Main Authors: Donatella Delle Cave, Silvia Buonaiuto, Bruno Sainz, Marco Fantuz, Maria Mangini, Alessandro Carrer, Annalisa Di Domenico, Tea Teresa Iavazzo, Gennaro Andolfi, Carme Cortina, Marta Sevillano, Christopher Heeschen, Vincenza Colonna, Marco Corona, Antonio Cucciardi, Martina Di Guida, Eduard Batlle, Annachiara De Luca, Enza Lonardo
Format: Article
Language:English
Published: BMC 2022-10-01
Series:Journal of Experimental & Clinical Cancer Research
Subjects:
Pancreatic ductal adenocarcinoma (PDAC)
Laminin γ2 (LAMC2)
Tumor-initiating cells (TICs)
TGF-β signaling
Vactosertib
Online Access:https://doi.org/10.1186/s13046-022-02516-w

Internet

https://doi.org/10.1186/s13046-022-02516-w

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