Additive Effect of Parathyroid Hormone and Zoledronate Acid on Prevention Particle Wears-Induced Implant Loosening by Promoting Periprosthetic Bone Architecture and Strength in an Ovariectomized Rat Model

Additive Effect of Parathyroid Hormone and Zoledronate Acid on Prevention Particle Wears-Induced Implant Loosening by Promoting Periprosthetic Bone Architecture and Strength in an Ovariectomized Rat Model

Implant-generated particle wears are considered as the major cause for the induction of implant loosening, which is more susceptible to patients with osteoporosis. Monotherapy with parathyroid hormone (PTH) or zoledronate acid (ZOL) has been proven efficient for preventing early-stage periprosthetic...

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Bibliographic Details
Main Authors: Chenhe Zhou, Yangxin Wang, Jiahong Meng, Minjun Yao, Huikang Xu, Cong Wang, Fanggang Bi, Hanxiao Zhu, Guang Yang, Mingmin Shi, Shigui Yan, Haobo Wu
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-04-01
Series:Frontiers in Endocrinology
Subjects:
implant loosening
osteolysis
osteoporosis
parathyroid hormone (1-34)
zoledronate (ZOL)
Online Access:https://www.frontiersin.org/articles/10.3389/fendo.2022.871380/full

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https://www.frontiersin.org/articles/10.3389/fendo.2022.871380/full

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