Intestinal Epithelial STAT6 Activation Rescues the Defective Anti-Helminth Responses Caused by <i>Ogt</i> Deletion

Intestinal Epithelial STAT6 Activation Rescues the Defective Anti-Helminth Responses Caused by <i>Ogt</i> Deletion

Dynamic regulation of intestinal epithelial cell (IEC) proliferation and differentiation is crucial for maintaining mucosa homeostasis and the response to helminth infection. O-GlcNAc transferase (OGT), an enzyme catalyzing the transfer of GlcNAc from the donor substrate UDP-GlcNAc onto acceptor pro...

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Bibliographic Details
Main Authors: Xiwen Xiong, Rong Huang, Zun Li, Chenyan Yang, Qingzhi Wang, Hai-Bin Ruan, Lin Xu
Format: Article
Language:English
Published: MDPI AG 2022-09-01
Series:International Journal of Molecular Sciences
Subjects:
OGT
tuft cell
goblet cell
helminth
STAT6
type 2 immunity
Online Access:https://www.mdpi.com/1422-0067/23/19/11137

Internet

https://www.mdpi.com/1422-0067/23/19/11137

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