AN ANTISENSE OLIGONUCLEOTIDE DERIVATIVE TO THE MRNA OF THE NAV1.5 SODIUM CHANNEL GENE (SCN5A) DECREASES THE HEART RATE

AN ANTISENSE OLIGONUCLEOTIDE DERIVATIVE TO THE MRNA OF THE NAV1.5 SODIUM CHANNEL GENE (SCN5A) DECREASES THE HEART RATE

Objective: To assess the potential of a new approach to altering the heart rate by expression inhibition of the SCN5A gene, encoding a classical sodium channel, Nav1.5, with an antisense oligonucleotide derivative in the case study of the mouse. Material and methods: C57BL/6J male mice; oligonucleot...

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Bibliographic Details
Main Authors: S. I. Oshevskii, Yu. I. Ragino, E. V. Kashtanova, Yu. V. Polonskaya, E. M. Stakhneva, V. P. Nikolin, N. A. Popova, N. A. Kolchanov, M. I. Voevoda
Format: Article
Language:Russian
Published: Siberian Branch of Russian Academy of Sciences, Research Institute of Internal and Preventive Medicine, branch of the Institute of Cytology and Genetics 2017-06-01
Series:Атеросклероз
Subjects:
antisense oligonucleotide derivative
scn5a gene
c57bl/6j mice
heart rate
Online Access:https://ateroskleroz.elpub.ru/jour/article/view/41/41

Internet

https://ateroskleroz.elpub.ru/jour/article/view/41/41

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