Nicotinamide mononucleotide adenylyltransferase uses its NAD+ substrate-binding site to chaperone phosphorylated Tau

Nicotinamide mononucleotide adenylyltransferase uses its NAD+ substrate-binding site to chaperone phosphorylated Tau

Tau hyper-phosphorylation and deposition into neurofibrillary tangles have been found in brains of patients with Alzheimer’s disease (AD) and other tauopathies. Molecular chaperones are involved in regulating the pathological aggregation of phosphorylated Tau (pTau) and modulating disease progressio...

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Bibliographic Details
Main Authors: Xiaojuan Ma, Yi Zhu, Jinxia Lu, Jingfei Xie, Chong Li, Woo Shik Shin, Jiali Qiang, Jiaqi Liu, Shuai Dou, Yi Xiao, Chuchu Wang, Chunyu Jia, Houfang Long, Juntao Yang, Yanshan Fang, Lin Jiang, Yaoyang Zhang, Shengnan Zhang, Rong Grace Zhai, Cong Liu, Dan Li
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2020-04-01
Series:eLife
Subjects:
Alzheimer's disease
tauopathy
phosphorylated Tau
chaperone
NMNAT
NAD synthase
Online Access:https://elifesciences.org/articles/51859

Internet

https://elifesciences.org/articles/51859

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