Nicotinamide mononucleotide adenylyltransferase uses its NAD+ substrate-binding site to chaperone phosphorylated Tau
Tau hyper-phosphorylation and deposition into neurofibrillary tangles have been found in brains of patients with Alzheimer’s disease (AD) and other tauopathies. Molecular chaperones are involved in regulating the pathological aggregation of phosphorylated Tau (pTau) and modulating disease progressio...
Main Authors: | Xiaojuan Ma, Yi Zhu, Jinxia Lu, Jingfei Xie, Chong Li, Woo Shik Shin, Jiali Qiang, Jiaqi Liu, Shuai Dou, Yi Xiao, Chuchu Wang, Chunyu Jia, Houfang Long, Juntao Yang, Yanshan Fang, Lin Jiang, Yaoyang Zhang, Shengnan Zhang, Rong Grace Zhai, Cong Liu, Dan Li |
---|---|
Format: | Article |
Language: | English |
Published: |
eLife Sciences Publications Ltd
2020-04-01
|
Series: | eLife |
Subjects: | |
Online Access: | https://elifesciences.org/articles/51859 |
Similar Items
-
In vitro and in silico study of an exclusive insertion in the nicotinamide/nicotinate mononucleotide adenylyltransferase from Leishmania braziliensis
by: Lesly Johanna Ortiz-Joya, et al.
Published: (2022-12-01) -
Protein-protein interactions of the nicotinamide/nicotinate mononucleotide adenylyltransferase of Leishmania braziliensis
by: Lesly Ortiz-Joya, et al.
Published: (2019-03-01) -
Structural insights into Plasmodium falciparum nicotinamide mononucleotide adenylyltransferase: oligomeric assembly
by: Luis Ernesto Contreras-Rodríguez, et al.
Published: (2018-07-01) -
Nicotinamide mononucleotide adenylyltransferase of Trypanosoma cruzi (TcNMNAT): a cytosol protein target for serine kinases
by: Diana Milena Sánchez-Lancheros, et al. -
Identification of the nicotinamide mononucleotide adenylyltransferase of Trypanosoma cruzi
by: Carlos H Niño, et al.
Published: (2015-11-01)