WTAP-mediated m6A modification of TRIM22 promotes diabetic nephropathy by inducing mitochondrial dysfunction via ubiquitination of OPA1

WTAP-mediated m6A modification of TRIM22 promotes diabetic nephropathy by inducing mitochondrial dysfunction via ubiquitination of OPA1

Objectives Diabetic nephropathy (DN) is one of the most serious microvascular complications of diabetes and is the most common cause of end-stage renal disease. Tripartite motif-containing (TRIM) proteins are a large family of E3 ubiquitin ligases that contribute to protein quality control by regula...

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Bibliographic Details
Main Authors: Zeng Zhang, Fengzhu Zhou, Min Lu, Duanchun Zhang, Xinyi Zhang, Siyu Xu, Yanming He
Format: Article
Language:English
Published: Taylor & Francis Group 2024-12-01
Series:Redox Report
Subjects:
WTAP
m6A
TRIM22
diabetic nephropathy
mitochondrial dysfunction
OPA1
Online Access:https://www.tandfonline.com/doi/10.1080/13510002.2024.2404794

Internet

https://www.tandfonline.com/doi/10.1080/13510002.2024.2404794

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