Study of the impact of different salts on the intrinsic dissolution rate of pharmaceutical compounds
The intrinsic dissolution rate (IDR) of a free base and its four salts were investigated with the aim of selecting the salt with the best dissolution performance. IDRs were measured using the Sirius inForm platform with quantitation by in-situ UV spectroscopy. Results showed that the hydrochloride s...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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University of Huddersfield Press
2017-12-01
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| Series: | British Journal of Pharmacy |
| Subjects: | |
| Online Access: | https://www.bjpharm.org.uk/article/id/43/ |
| Summary: | The intrinsic dissolution rate (IDR) of a free base and its four salts were investigated with the aim of selecting the salt with the best dissolution performance. IDRs were measured using the Sirius inForm platform with quantitation by in-situ UV spectroscopy. Results showed that the hydrochloride salt had the highest dissolution rate followed by the maleate and p- toluenesulphonate salts, whilst the naphthalene-2-sulphonate and free base had the lowest IDR values. The Sirius inForm provides valuable insights into the dissolution behaviour of different drug forms during salt selection.
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| ISSN: | 2058-8356 |