Assessing the Therapeutic Efficacy of Proton Transport Inhibitors in a Triple-Negative Breast Cancer Murine Model with Magnetic Resonance Imaging—Chemical Exchange Saturation Transfer Tumor pH Imaging

Assessing the Therapeutic Efficacy of Proton Transport Inhibitors in a Triple-Negative Breast Cancer Murine Model with Magnetic Resonance Imaging—Chemical Exchange Saturation Transfer Tumor pH Imaging

Proton transporters play a key role in maintaining the acidic tumor microenvironment; hence, their inhibition has been proposed as a new therapeutic treatment, although few methods can accurately assess their effect in vivo. In this study, we investigated whether MRI-CEST (Magnetic Resonance Imaging...

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Bibliographic Details
Main Authors: Chetan Dhakan, Annasofia Anemone, Vittoria Ventura, Antonella Carella, Alessia Corrado, Elisa Pirotta, Daisy Villano, Feriel Romdhane, Francesco Gammaraccio, Silvio Aime, Dario Livio Longo
Format: Article
Language:English
Published: MDPI AG 2023-11-01
Series:Metabolites
Subjects:
breast cancer
proton pump inhibitor
4T1
triple-negative breast cancer
pH imaging
chemical exchange saturation transfer (CEST)
Online Access:https://www.mdpi.com/2218-1989/13/11/1161

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https://www.mdpi.com/2218-1989/13/11/1161

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