Eurycomanone stimulates bone mineralization in zebrafish larvae and promotes osteogenic differentiation of mesenchymal stem cells by upregulating AKT/GSK-3β/β-catenin signaling

Eurycomanone stimulates bone mineralization in zebrafish larvae and promotes osteogenic differentiation of mesenchymal stem cells by upregulating AKT/GSK-3β/β-catenin signaling

Background: Eurycomanone (EN) is a diterpenoid compound isolated from the roots of Eurycoma longifolia (E. longifolia). Previous studies have confirmed that E. longifolia can enhance bone regeneration and bone strength. We previously isolated and identified ten quassinoids from E. longifolia, and th...

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Bibliographic Details
Main Authors: Yan-ting Zhong, Hong-bo Liao, Zhi-qiang Ye, Hua-sheng Jiang, Jia-xiao Li, Lin-mao Ke, Jun-ying Hua, Bo Wei, Xin Wu, Liao Cui
Format: Article
Language:English
Published: Elsevier 2023-05-01
Series:Journal of Orthopaedic Translation
Subjects:
Eurycomanone
Bone formation
Zebrafish larvae
Human mesenchymal stem cells
C3H10 cells
AKT/GSK-3β/β-catenin signaling pathway
Online Access:http://www.sciencedirect.com/science/article/pii/S2214031X23000335

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