An Improved Process for Repaglinide via an Efficient and One Pot Process of (1S)-3-methyl-1-(2-piperidin-1-ylphenyl)butan-1-amine – A Useful Intermediate
The development of a large-scale synthesis for (1S)-3-methyl-1-(2-piperidin-1-ylphenyl)butan-1-amine (S-(+)-1), a key intermediate of repaglinide (2), is described. The process conditions for S-(+)-1 involving nucleophilic substitution, Grignard reaction, reduction and resolution were opti...
Main Authors: | , , , , , , , , |
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Format: | Article |
Language: | deu |
Published: |
Swiss Chemical Society
2006-09-01
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Series: | CHIMIA |
Subjects: | |
Online Access: | https://chimia.ch/chimia/article/view/4212 |