An Improved Process for Repaglinide via an Efficient and One Pot Process of (1S)-3-methyl-1-(2-piperidin-1-ylphenyl)butan-1-amine – A Useful Intermediate

An Improved Process for Repaglinide via an Efficient and One Pot Process of (1S)-3-methyl-1-(2-piperidin-1-ylphenyl)butan-1-amine – A Useful Intermediate

The development of a large-scale synthesis for (1S)-3-methyl-1-(2-piperidin-1-ylphenyl)butan-1-amine (S-(+)-1), a key intermediate of repaglinide (2), is described. The process conditions for S-(+)-1 involving nucleophilic substitution, Grignard reaction, reduction and resolution were opti...

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Bibliographic Details
Main Authors: Naveenkumar Kolla, Chandrashekar R. Elati, Pravinchandra J. Vankawala, Srinivas Gangula, Eswaraiah Sajja, Yerremilli Anjaneyulu, Apurba Bhattacharya, Venkataraman Sundaram, Vijayavitthal T. Mathad
Format: Article
Language:deu
Published: Swiss Chemical Society 2006-09-01
Series:CHIMIA
Subjects:
1,3-dicyclohexyl urea impurity
Grignard reaction
Racemization
Repaglinide
Resolution
Snar reaction
Online Access:https://chimia.ch/chimia/article/view/4212

Internet

https://chimia.ch/chimia/article/view/4212

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