Regulation of the hippocampal translatome by Apoer2-ICD release

Regulation of the hippocampal translatome by Apoer2-ICD release

Abstract Background ApoE4, the most significant genetic risk factor for late-onset Alzheimer’s disease (AD), sequesters a pro-synaptogenic Reelin receptor, Apoer2, in the endosomal compartment and prevents its normal recycling. In the adult brain, Reelin potentiates excitatory synapses and thereby p...

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Bibliographic Details
Main Authors: Catherine R. Wasser, Gordon C. Werthmann, Eric M. Hall, Kristina Kuhbandner, Connie H. Wong, Murat S. Durakoglugil, Joachim Herz
Format: Article
Language:English
Published: BMC 2023-09-01
Series:Molecular Neurodegeneration
Subjects:
Apoer2
Alzheimer’s TRAP-Seq
Synaptic homeostasis
Reelin
ApoE
Alternative splicing
Online Access:https://doi.org/10.1186/s13024-023-00652-1

Internet

https://doi.org/10.1186/s13024-023-00652-1

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