A zebrafish model of crim1 loss of function has small and misshapen lenses with dysregulated clic4 and fgf1b expression

A zebrafish model of crim1 loss of function has small and misshapen lenses with dysregulated clic4 and fgf1b expression

IntroductionHeterozygous deletions predicting haploinsufficiency for the Cysteine Rich Motor Neuron 1 (CRIM1) gene have been identified in two families with macrophthalmia, colobomatous, with microcornea (MACOM), an autosomal dominant trait. Crim1 encodes a type I transmembrane protein that is expre...

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Autors principals: Tien Le, Stephanie Htun, Manoj Kumar Pandey, Yihui Sun, Albert Frank Magnusen, Ehsan Ullah, Julie Lauzon, Shannon Beres, Chung Lee, Bin Guan, Robert B. Hufnagel, Brian P. Brooks, Sergio E. Baranzini, Anne Slavotinek
Format: Article
Idioma:English
Publicat: Frontiers Media S.A. 2025-03-01
Col·lecció:Frontiers in Cell and Developmental Biology
Matèries:
cysteine-rich motor neuron 1
zebrafish
lens development
RNA-seq
colobomatous macrophthalmia with microcornea
coloboma
Accés en línia:https://www.frontiersin.org/articles/10.3389/fcell.2025.1522094/full

Internet

https://www.frontiersin.org/articles/10.3389/fcell.2025.1522094/full

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