Omicron BA.1 Mutations in SARS-CoV-2 Spike Lead to Reduced T-Cell Response in Vaccinated and Convalescent Individuals

Omicron BA.1 Mutations in SARS-CoV-2 Spike Lead to Reduced T-Cell Response in Vaccinated and Convalescent Individuals

Omicron BA.1 variant can readily infect people with vaccine-induced or naturally acquired SARS-CoV-2 immunity facilitated by escape from neutralizing antibodies. In contrast, T-cell reactivity against the Omicron BA.1 variant seems relatively well preserved. Here, we studied the preexisting T cells...

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Bibliographic Details
Main Authors: Maarten E. Emmelot, Martijn Vos, Mardi C. Boer, Nynke Y. Rots, Jelle de Wit, Cécile A. C. M. van Els, Patricia Kaaijk
Format: Article
Language:English
Published: MDPI AG 2022-07-01
Series:Viruses
Subjects:
SARS-CoV-2
Omicron BA.1 variant
mutations
T-cell response
vaccination
natural infection
Online Access:https://www.mdpi.com/1999-4915/14/7/1570

Internet

https://www.mdpi.com/1999-4915/14/7/1570

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