TREM2 improves microglia function and synaptic development in autism spectrum disorders by regulating P38 MAPK signaling pathway

TREM2 improves microglia function and synaptic development in autism spectrum disorders by regulating P38 MAPK signaling pathway

Abstract Background Autism spectrum disorder (ASD) encompasses a diverse range of neurodevelopmental disorders, but the precise underlying pathogenesis remains elusive. This study aim to explore the potential mechanism of TREM2 in regulating microglia function in ASD. Materials and methods The offsp...

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Bibliographic Details
Main Authors: Yi Tian, Xiao Xiao, Weiliang Liu, Shanqing Cheng, Na Qian, Ling Wang, Yang Liu, Rong Ai, Xiaoping Zhu
Format: Article
Language:English
Published: BMC 2024-02-01
Series:Molecular Brain
Subjects:
Autism spectrum disorder
Triggering receptor expressed on myeloid cells-2
Microglial cells
Synaptic
Valproic acid
P38 MAPK pathway
Online Access:https://doi.org/10.1186/s13041-024-01081-x

Internet

https://doi.org/10.1186/s13041-024-01081-x

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