Ameliorative inhibition of sirtuin 6 by imidazole derivative triggers oxidative stress-mediated apoptosis associated with Nrf2/Keap1 signaling in non-small cell lung cancer cell lines

Ameliorative inhibition of sirtuin 6 by imidazole derivative triggers oxidative stress-mediated apoptosis associated with Nrf2/Keap1 signaling in non-small cell lung cancer cell lines

Background: Redox homeostasis is the vital regulatory system with respect to antioxidative response and detoxification. The imbalance of redox homeostasis causes oxidative stress. Nuclear factor-erythroid 2 p45-related factor 2 (Nrf2, also called Nfe2l2)/Kelchlike ECH-associated protein 1 (Keap1) si...

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Bibliographic Details
Main Authors: Uma Maheswara Rao Dindi, Sameer Al-Ghamdi, Naif Abdurhman Alrudian, Salman Bin Dayel, Abdulwahab Ali Abuderman, Mohammed Saad Alqahtani, Nasraddin Othman Bahakim, Thiyagarajan Ramesh, Ravikumar Vilwanathan
Format: Article
Language:English
Published: Frontiers Media S.A. 2024-01-01
Series:Frontiers in Pharmacology
Subjects:
Epigenetics
SIRT6
HDAC
HDACi
KEAP1
Nrf2
Online Access:https://www.frontiersin.org/articles/10.3389/fphar.2023.1335305/full

Internet

https://www.frontiersin.org/articles/10.3389/fphar.2023.1335305/full

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