Anti-Inflammatory, Antioxidant, and WAT/BAT-Conversion Stimulation Induced by Novel PPAR Ligands: Results from Ex Vivo and In Vitro Studies

Anti-Inflammatory, Antioxidant, and WAT/BAT-Conversion Stimulation Induced by Novel PPAR Ligands: Results from Ex Vivo and In Vitro Studies

Activation of peroxisome proliferator-activated receptors (PPARs) not only regulates multiple metabolic pathways, but mediates various biological effects related to inflammation and oxidative stress. We investigated the effects of four new PPAR ligands containing a fibrate scaffold—the PPAR agonists...

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Bibliographic Details
Main Authors: Lucia Recinella, Barbara De Filippis, Maria Loreta Libero, Alessandra Ammazzalorso, Annalisa Chiavaroli, Giustino Orlando, Claudio Ferrante, Letizia Giampietro, Serena Veschi, Alessandro Cama, Federica Mannino, Irene Gasparo, Alessandra Bitto, Rosa Amoroso, Luigi Brunetti, Sheila Leone
Format: Article
Language:English
Published: MDPI AG 2023-02-01
Series:Pharmaceuticals
Subjects:
adipose tissue
UCP1
PPAR modulators
obesity
Online Access:https://www.mdpi.com/1424-8247/16/3/346

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https://www.mdpi.com/1424-8247/16/3/346

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